CEDARS-SINAI MEDICAL CENTER

• THE REGENTS OF THE UNIVERSITY OF COLORADO

  UEI SPVKK1RC2MZ3 · not in the directory yet

  $429K

  Subcontractor to this prime · 1 sub-award · latest Jun 30, 2026

  • National Aeronautics and Space Administration
  • “STATEMENT OF WORK FOR PROJECT ENTITLED “IN SPACE BIOMANUFACTURING OF INDUCED PLURIPOTENT STEM CELLS FOR REGENERATIVE MEDICINE APPLICATIONS ON EARTH” BACKGROUND AND EXPERIENCE: I FOUNDED THE TRANSPLANT AND STEM CELL IMMUNOBIOLOGY (TSI) LAB IN 2009, AND I AM CURRENTLY APPOINTED AS ACTING PROFESSOR IN THE DEPARTMENT OF SURGERY AT CEDARS SINAI. I HAVE A SUCCESSFUL TRACK RECORD OF OVER 20 YEARS IN PERFORMING RESEARCH FOCUSED ON PLURIPOTENT STEM CELLS (PSC) IMMUNOBIOLOGY AND PRE-CLINICAL AS WELL AS TRANSLATIONAL AND CLINICAL STUDIES. WE USE A COMBINATION OF MOLECULAR/CELLULAR BIOLOGY, GENOMIC/EPIGENOMIC PROFILING, TISSUE ENGINEERING, AND MOLECULAR IMAGING TECHNOLOGIES TO BETTER UNDERSTAND STEM CELL BIOLOGY IN VITRO AND IN VIVO. WE HAVE MADE SIGNIFICANT CONTRIBUTIONS TO SPACEFLIGHT MEDICINE STUDYING THE EFFECT OF MICROGRAVITY AND SPACEFLIGHT ON VASCULAR HEALTH, IMMUNE CELLS, AND STEM CELLS SUPPORTED BY NASA, NIH/CASIS AND NSF GRANTS. OUR RESEARCH WAS ON 3 DIFFERENT SPACEX MISSIONS ON THE ISS. PROPOSED EXPERIMENT: THE “IN SPACE BIOMANUFACTURING OF INDUCED PLURIPOTENT STEM CELLS FOR REGENERATIVE MEDICINE APPLICATIONS ON EARTH” PROJECT ATTEMPTS TO UTILIZE THE UNIQUE ENVIRONMENT OF MICROGRAVITY TO DEVELOP IPSC MANUFACTURING PROCESSES AT LARGER SCALE. PROPOSED WORKPLAN: THE SCHREPFER LAB AT CEDARS SINAI WILL PROVIDE IPSC, PROCESS DEVELOPMENT AND ANALYTICS SUPPORT FOR PROJECT GOALS ASSOCIATED WITH FLIGHTS 1 AND 2 (TABLE 1). FLIGHT 1: 1. WORK CLOSELY WITH BIOSERVE TEAM TO OPTIMIZE SMALL SCALE IPSC CULTURE SYSTEMS COMPATIBLE WITH CURRENT HARDWARE. 2. CONDUCT INDEPENDENT LAB TESTING OF THE FLIGHT PROTOCOL IN CEDAR-SINAI’S LABS WITH BIOSERVE PROVIDED FLIGHT HARDWARE. 3. PERFORM ANALYTICS FOR ALL SAMPLES GENERATED DURING GROUND AND ISS STUDIES, INCLUDING: FLOW CYTOMETRY, QPCR, GENETIC ASSESSMENT, AND RNASEQ. FLIGHT 2: 1. WORK CLOSELY WITH BIOSERVE TEAM TO OPTIMIZE LARGE SCALE IPSC AND IPSC-HE CULTURE SYSTEMS COMPATIBLE WITH NEWLY DEVELOPED HARDWARE. 2. CONDUCT INDEPENDENT LAB TESTING”
• LEIDOS, INC.

  UEI MYKLJHTX3MM7

  $399.2K

  Subcontractor to this prime · 1 sub-award · latest Jun 8, 2026

  • National Aeronautics and Space Administration
  • “PROCURED GOODS AND/OR SERVICES BETWEEN 01-OCT-24 AND 30-SEP-26 IN SUPPORT OF CONTRACT SOW.”

No reported sub-awards as a prime contractor.

Agencies generally may not award to excluded parties, and primes may not subcontract with them above the threshold in FAR 52.209-6 (except COTS items) without a compelling reason reported to the contracting officer (FAR 9.405, 9.405-2). Some exclusion types apply only to specific programs: read the record on SAM.gov.