LOW EARTH ORBIT BIOSCIENCES LLC

• THE REGENTS OF THE UNIVERSITY OF COLORADO

  UEI SPVKK1RC2MZ3 · not in the directory yet

  $82.5K

  Subcontractor to this prime · 1 sub-award · latest Mar 24, 2026

  • National Aeronautics and Space Administration
  • “CONTRACT OVERVIEW THIS CONTRACT IS REQUESTED FOR LOW EARTH ORBIT BIOSCIENCES TO PROVIDE MISSION INTEGRATION AND OPERATION SERVICES FOR MANIFEST AND LAUNCH OF THE PAYLOAD TO THE INTERNATIONAL SPACE STATION FOR THE INVESTIGATION TITLED: “SCALABLE COMMERCIAL BIOMANUFACTURING IN LOW EARTH ORBIT” FROM WILLIAM MCLAMB, PHD, AT LOW EARTH ORBIT BIOSCIENCES LLC. PURPOSE THIS STATEMENT OF WORK IDENTIFIES THE SCIENCE AND ENGINEERING REQUIREMENTS FOR CONDUCTING THE PROPOSED INVESTIGATION ON THE INTERNATIONAL SPACE STATION (ISS) NATIONAL LABORATORY AND IDENTIFIES THE MISSION INTEGRATION AND OPERATIONS SERVICES NEEDED FOR MANIFESTING AND LAUNCHING THE PAYLOAD TO THE ISS. THE INVESTIGATION IS TITLED: “SCALABLE COMMERCIAL BIOMANUFACTURING IN LOW EARTH ORBIT”. OVERVIEW/EXPERIMENT SUMMARY THE GOAL OF THIS PROJECT IS TO SUCCESSFULLY DEVELOP, INTEGRATE AND OPERATE SCALABLE BIOREACTOR TECHNOLOGY DEVICES ON ISS AND DEMONSTRATE MEASURABLE PERFORMANCE RESULTS. PI INTENDS TO DEMONSTRATE AND ADVANCE MULTIPLE NEW CAPABILITIES: 1) AUTOMATED CELL CULTURE, 2) PRECISION FLUID HANDLING, 3) FLUID/SAMPLE AGITATION, 4) IN SITU MEASUREMENT, 5) CRYOGENIC HANDLING AND 6) AUTOMATED CELL COUNTING. THE PROPOSED OBJECTIVES FOR THE ISS PHASE ARE: GOAL 2-0: DEMONSTRATE FEASIBILITY OF MANUFACTURING IPSCS USING SELECTED BIOREACTOR SYSTEM. ALTERNATIVE SUSPENSION CELL MODELS COULD BE USED THAT ARE ALSO SUITABLE FOR EXPANSION AND RELEVANT TO CELL AND GENE THERAPY. CELL MODELS WILL BE EVALUATED AND SELECTED DURING GROUND TESTING (AND COULD INCLUDE: SF9 CELLS, CD8+ T CELLS, HEK293 CELLS, AND MONOCYTIC CELL LINES SUCH AS THP-1). CELLS WILL BE THAWED INTO THE BIOREACTOR SYSTEM, PASSAGED AT LEAST 2 TIMES, AND THEN CRYOPRESERVED. CELLS WILL BE EVALUATED AT EACH PASSAGE USING THE KERMIT MICROSCOPE OR BIOSERVE INVERTED MICROSCOPE AND/OR PI-PROVIDED AUTOMATED CELL COUNTER. CRYOPRESERVED CELLS, FROZEN MEDIA AND FROZEN CELL PELLETS SAMPLES WILL BE TRANSPORTED BACK TO PI LAB FOR ASSESSMENT. THESE STUDIES WILL INCLUDE THE USE O”

No reported sub-awards as a prime contractor.

Agencies generally may not award to excluded parties, and primes may not subcontract with them above the threshold in FAR 52.209-6 (except COTS items) without a compelling reason reported to the contracting officer (FAR 9.405, 9.405-2). Some exclusion types apply only to specific programs: read the record on SAM.gov.

No confirmed match on the Consolidated Screening List (screened Nov 13, 2026).

The list combines Commerce, State and Treasury export-control and sanctions lists. A “no match” result is a name-and-address screen, not an export-compliance determination.